Research interests

Misuse of antibiotics has induced the generation of a whole population of MDR (Multidrug resistant) bacteria. For instance, the mistreatment or misdiagnosis of patients with inappropriate antibiotics, coupled with insufficient knowledge of the origin of infection, has cast a shadow over the antibiotic medical miracle. To avoid the eruption of MDR bacteria as superbugs, understanding the underlined mechanisms by which bacteria acquire antibiotic resistance very rapidly and their use in the development of new antibacterials are necessary.

The key subjects on above topics

Major topics of RNBL

Regulation of antibiotic resistance: identification of novel antibacterial target genes and seeking for the combinatorial materials to improve the efficacy of current last-resort antibiotics
Applications of the newly identified knowledge to both the diagnosis and treatment of specific antibiotic resistant superbugs by new-concept antibacterials.
Identification and development of new biologically non-toxic materials in killing G(-) and G(+) bacteria
Development of new concept antibiotics and vaccines against infectious diseases
Biogenesis of Outermembrane vesicles and their applications in the vaccine development

Mechanisms that control the expression and decay of cellular RNAs by environmental stresses
Unraveling the role of bacterial and eukaryotic small noncoding RNAs in infectious or human diseases
Synthesis of new nanomaterial platforms
Design new vaccine production systems for infectious diseases
Chemical screening for functional molecules against infectious diseases

Keywords

Ribonuclease, Small noncoding RNA, Pathogen, Black phosphorus, Nanoantibiotics, Nanoparticles, Nanocomposites, Antibiotic resistance, Trans-acting regulators, Biofilm, Outer membrane Vesicles, Proteomics, RNomics, Operon, RNA decay